Training on Faster COVID-19 Testing
CSIR - Centre for Cellular & Molecular Biology
Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India
Senior Principal Scientist
Email: raghu@ccmb.res.in
Phone: +91-040-27192924
Research Interests
The extraordinary success of Mycobacterium tuberculosis (M.tb), the etiologic agent of human tuberculosis (TB), has been attributed to its ability to modulate host immune responses, facilitating its long term persistence. We believe that understanding the basic biology of the pathogen and its interactions with the host, is the best way forward towards the development of improved diagnostic reagents, vaccines and novel anti-TB drugs. Research in our laboratory is focussed towards the identification of bacillary virulence factors, characterising the events at the host-pathogen interface, and the discovery of novel antibiotic resistance mechanisms.
Selected Publications
Savanagouder, M.*, Mukku R.P.*, Yeruva, C.V., Nagarajan, N., Peddapuvala U.K., Sharma, Y. and Raghunand, T. R. (2024) Dissecting the Ca2+ dependence of Mycobacterium tuberculosis DesA1 function. Manuscript Accepted FEBS Letters BioRxiv https://doi.org/10.1101/2023.03.31.535087
Ramachandran, G., Yeruva, C.V., Swarup, G. and Raghunand, T. R. (2024) A cytoprotective role for optineurin during mycobacterial infection of macrophages. Biochemistry and Biophysics Rep. 38: 101672. doi: 10.1016/j.bbrep.2024.101672
Mukku R.P., Poornima, K., Yadav, S. and Raghunand, T. R.(2023) Delineating the functional role of the PPE50 (Rv3135) - PPE51 (Rv3136) gene cluster in the pathophysiology of Mycobacterium tuberculosis. Microbes and Infection. https://doi.org/10.1016/j.micinf.2023.105248
Kishore, V, Gaiwala, S.G., and Raghunand, T. R. (2023) Septum site placement in Mycobacteria - Identification and Characterization of Mycobacterial homologues of Escherichia coli MinD. Microbiology 169:001359 DOI 10.1099/mic.0.001359
Dutta, A., Mukku, R.P., Kumar, G. A., Md. Jafurulla, Raghunand, T. R* and Chattopadhyay, A.* (2022) Integrity of the Actin Cytoskeleton of Host Macrophages is Necessary for Mycobacterial Entry. J Membrane Biol 255:623-632 https://doi.org/10.1007/s00232-022-00217-1. This article featured on the cover page of the journal
Education & Experience
| P.G: | Biotechnology ; Indian Institute of Technology, Bombay, India ; 1994 |
| Ph.D: | Molecular Analysis of beta-glucoside utilisation in Klebsiella aerogenes ; Indian Institute of Science, Bangalore, India ; 2001 |
| Post.Doc: | Mycobacterial Pathogenesis ; Johns Hopkins School of Medicine, Baltimore, USA ; 2001-2007 |
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| Title | Journal | Year |
|---|---|---|
| Dissecting the Ca2+ dependence of Mycobacterium tuberculosis DesA1 function | FEBS Letters | 2024 |
| A cytoprotective role for optineurin during mycobacterial infection of macrophages. | Biochemistry and Biophysics Reports | 2024 |
| Delineating the functional role of the PPE50 (Rv3135) - PPE51 (Rv3136) gene cluster in the pathophysiology of Mycobacterium tuberculosis | Microbes and Infection | 2023 |
| Septum site placement in Mycobacteria - Identification and Characterization of Mycobacterial homologues of Escherichia coli MinD | Microbiology | 2023 |
| Integrity of the Actin Cytoskeleton of Host Macrophages is Necessary for Mycobacterial Entry | The Journal of Membrane Biology | 2022 |
| Optineurin modulates ER stress-induced signaling pathways and cell death | Biochemical and Biophysical Research Communications | 2020 |
| Macrophage sphingolipids are essential for the entry of mycobacteria | Chem Phys Lipids 213:25-31 | 2018 |
| Insights into the function of FhaA, a cell-division associated protein in mycobacteria. | FEMS Microbiology Letters 364 (2):fnw294 | 2017 |
| Identification of mycobacterial genes involved in β-lactam sensitivity - Implications in treatment of tuberculosis with β-lactam containing regimens | Antimicrobial Agents and Chemotherapy 61(7) e00425-17. https://doi .org/10.1128/AAC.00425-17 | 2017 |
| Identification of Novel Loci Associated with Mycobacterial Isoniazid Resistance | Tuberculosis 96:21-26 | 2016 |
| The PE_PGRS proteins of Mycobacterium tuberculosis are Ca2+ binding mediators of host-pathogen interaction | Biochemistry(ACS)55(33):4675-87 | 2016 |
| Identification and functional annotation of mycobacterial septum formation genes using cell division mutants of Escherichia coli | Res Microbiol, 167(2):142-8 | 2016 |
| The Mycobacterium tuberculosis desaturase DesA1 (Rv0824c) is a Ca2+ binding protein | Biochem Biophys Res Comm 480(1):29-35 | 2016 |
| The Mycobacterium tuberculosis protein pair PE9 (Rv1088) - PE10 (Rv1089) forms heterodimers and induces macrophage apoptosis through TLR4 | Cellular Microbiol 17(11): 1653-1669 | 2015 |
| Dissecting the Membrane Cholesterol Requirement for Mycobacterial Entry into Host Cells | Chem Phys Lipids 189:19-27 | 2015 |
| Identifying novel mycobacterial stress associated genes using a random mutagenesis screen in Mycobacterium smegmatis | Gene 574(1):20-27 | 2015 |
| An immunomodulatory role for the Mycobacterium tuberculosis RD1 locus proteins PE35 (Rv3872) and PPE68 (Rv3873) | Febs J 281:1556-70 | 2014 |
| The Mycobacterium tuberculosis PE Proteins Rv0285 and Rv1386 Modulate Innate Immunity and Mediate Bacillary Survival in Macrophages | PLoS ONE 7(12): e51686. doi:10.1371/journal.pone.0051686 | 2012 |
| Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis | Tuberculosis (Edinb) 91S1:S61-S65. Epub 2011 Nov 23 | 2011 |
| Methionine Aminopeptidases from Mycobacterium tuberculosis as Novel Antimycobacterial Targets | Chemistry and Biology. 17(1):86-97 | 2010 |
| A Reproducible Bronchoscopic Model of Cavitary Tuberculosis Using Tuberculin-Sensitized Infected Outbred Rabbits | Infect.& Immunity.77(2):598-603 | 2008 |
| Mapping essential domains of Mycobacterium smegmatis WhmD: Insights into WhiB structure and function | J. Bacteriol.188 (19): 6966-6976 | 2006 |
| Mycobacterium smegmatis whmD and its homologue Mycobacterium tuberculosis whiB2 are functionally equivalent. | Microbiology 152(9): 2735-2747 | 2006 |
| Towards establishing a method to screen for inhibitors of essential genes in mycobacteria: Evaluation of the Acetamidase promoter | Int. J. Antimicrob. Agents 28(1): 37-42 | 2006 |
| Regulation of the expression of whiB1 in Mycobacterium tuberculosis: Role of cAMP receptor protein | Microbiology 152(9): 2749-2756 | 2006 |
| Differential gene expression in response to antibiotic exposure, growth phase, and stress conditions among the seven Mycobacterium tuberculosis whiB-like genes | Antimicrob. Agents Chemother. 50(8):2836-2841 | 2006 |
| Deletion of a Mycobacterium tuberculosis proteasomal ATPase homologue produces a slow growing strain which persists in host tissues | J. Infect. Dis.194:1233-1240 | 2006 |
| Mutational analysis of β-glucoside utilisation in Klebsiella aerogenes: evidence for the presence of multiple genetic systems | J. Genetics. 83(3): 285-289 | 2004 |
| The beta-glucoside genes of Klebsiella aerogenes: conservation and divergence in relation to the cryptic bgl genes of Escherichia coli. | FEMS Microbiol. Lett. 223(2):267-74 | 2003 |
| Transgene Silencing: New insights into an old puzzle. | J Biosciences 23(5): 539-540 | 1998 |
| Characterisation of 3 | Gene 190:69-76 | 1997 |
| Molecular clues to the control of circadian rhythms. | Resonance 1(4): 76-81 | 1996 |
2924
raghu@ccmb.res.in
2930
korak.chakraborty@ccmb.res.in
2930
simran.sharma@ccmb.res.in
2930
rohitmacharekar@ccmb.res.in
List of provisionally selected candidates against Notif.No:02/2022