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CSIR - Centre for Cellular & Molecular Biology

Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India

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V Radha

Emeritus Scientist
Email: vradha@ccmb.res.in
Phone: +91-040-27192619

Research Interests

Choice of a cell to undergo differentiation, division, or cell death forms the basis of development and functioning of tissues in multi-cellular organisms. Our interest has been in understanding the molecular players that regulate gene expression and cytoskeletal remodelling to guide cells to achieve specialized properties and form functional tissues. How these molecules respond to extracellular cues and simultaneously regulate multiple properties of the cell spatially and temporally has been our challenge. Salient findings have been, identification of the guanine nucleotide exchange factor, RapGEF1 as a regulator of actin dynamics, differentiation, and survival. RapGEF1 functions as a suppressor of ?-catenin and regulates chromatin dynamics. We have shown novel mechanisms of c-Abl and Bcr-Abl regulation, and our work has provided leads to understanding control of cell fate, and reversing the malignant phenotype of some human cancers. Ongoing work explores the molecular mechanisms involved in regulation of proliferation vs. differentiation in cells during development, and maintenance of homeostasis in adult tissues. Using cells in culture, we model physiological differentiation, and use human disease associated mutants to understand pathophysiology.

Selected Publications

Sanjeev Chavan Nayak, Vegesna Radha* (2020). C3G localizes to the mother centriole dependent on cenexin, and regulates centrosome duplication and primary cilia length. Journal of Cell Science 133(11) jcs.243113 doi: 10.1242/jcs.243113.

Raghawan A K, Rajashree R, Radha V*, and Swarup G*. (2019) HSC70 regulates   cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4. Proc Natl Acad Sci, USA 116 (41), 20243-20244.

Dhruvkumar Shakyawar, Muralikrishna Bhattiprolu & Vegesna Radha* (2018) "C3G dynamically associates with nuclear speckles and regulates mRNA splicing". Mol Biol Cell 29(9):1111-1124.

Shakyawar DK, Dayma K, Ramadhas A, Varalakshmi C, Radha V*.(2017) C3G shows regulated nucleo-cytoplasmic exchange and represses histone modifications associated with euchromatin. Mol Biol Cell. 28: 984-995, 2017K.

Sasi Kumar, A. Ramadhas, S.C. Nayak, S. Kaniyappan,  K. Dayma, V.Radha*(2015) C3G (RapGEF1), a regulator of actin dynamics promotes survival and myogenic differentiation of mouse mesenchymal cells. BBA-Mol. Cell Res. 1853: 2629-2639.

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Publications

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V Radha

Emeritus Scientist

2619

vradha@ccmb.res.in

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Divya Sriram

Senior Research Fellow

2648

divyasriram10@ccmb.res.in

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Shivaranjani C Moharir

Senior Research Fellow

2615

shivranjani@ccmb.res.in